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Chromium is an essential nutrient involved in the homeostatic control of blood glucose. Deficiency of this nutrient has been associated with hyperglycaemia, which is reversible by supplementation. Playing an integral role in the insulin receptor in mammalian tissues, supplementation of chromium has shown beneficial objective and subjective clinical outcomes in the treatment of both type 1 and type 2 diabetes mellitus as well as hyper- and hypoglycaemia. Chromium supplementation has also shown positive outcomes in the management of cholesterol levels, DHEA, and osteoporosis.